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What Causes Bipolar Disorder about.com The Diathesis-Stress Model says that "each person inherits certain physical predispositions that leave him or her vulnerable to problems that may or may not appear, depending on what kinds of situations that person confronts" (Bernstein et al., 2000
Kindling About.com an informative easy to read explanation of kindling... initial periods of cycling may begin with an environmental stressor, but if the cycles continue or occur unchecked, the brain becomes kindled or sensitized - pathways inside the central nervous system are reinforced so to speak - and future episodes of depression, hypomania, or mania will occur by themselves (independently of an outside stimulus), with greater and greater frequency quoted from The Bipolar Child Demitri and Janice Papolos
The Kindling Model Revisited about com

Family-of-Origin Characteristics in Bipolar Disorder: A Controlled Study  Robert G Cooke, MD, FRCPC1, L Trevor Young, MD, PhD, FRCPC2, Linda Mohri, MSW, CSW3, Pamela Blake, MSW, CSW4, Russell T Joffe, MD, FRCPC5
Conclusions: The results do not support the hypothesis that specific family attributes contribute to the development of bipolar disorder. (Can J Psychiatry 1999;44:379–381)
 

Disruptions In Sleep Routines May Lead To Mania In Manic Depressives June 19,1997 Doctor's Guide ....the likelihood that a manic episode will occur can be reduced by following very regular daily routines and involving family members

Are steroid medications really destabilizing-

Antidepressant-Induced Mania in Bipolar Patients: Identification of Risk Factors Medscape 2002 Particular attention should be paid to patients with a hyperthymic temperament, who have a greater risk of mood switches

 

More articles on theories and studies of genetic and neurological causes can be found on research page